By JOE LEE and JOEL SELZMAN-WITNIGERENSource Medical News Now title Scientists find new human gut-brain connection that can predict the diagnosis of breast cancer in mice, study findsArticle By JOEL SELLMAN-WHITNEY, M.D.
Associated PressMay 19, 2018 10:55AMUpdated May 19, 2019 12:09PMPublished by Associated PressMay 20, 2018 08:16AMScientists have discovered a connection between the gut microbiome and the development of human cancer.
They found that the bacteria found in the stomach and intestines of mice are able to predict whether a person will develop the disease in mice.
They also found that certain bacteria can be used to detect a person’s cancer in the gut.
The research was published online this week in the journal Cell.
“It’s a major step forward in understanding how the microbiome is shaping human health, and also how it may be contributing to cancer risk,” said lead researcher, Eric Lippert, a professor of microbiology and immunology at Duke University Medical Center.
The new study, led by the Duke Cancer Center, looked at mice.
The mice had been fed a diet containing a diet rich in Bifidobacterium longum, a common food source for the human gut microbiome.
They were also fed a high-fat, high-carbohydrate diet.
The mice that had been raised on a high fat diet had an increased risk of cancer.
The risk was also higher in mice that were given a low-fat diet and a high carbohydrate diet.
Both the high- and low-carb diets were linked to a decrease in the numbers of the immune cells that fight cancer, the researchers found.
This was seen in mice with cancer, but it also affected mice that ate the low-calorie diet.
The low- fat diet did not have an effect.
The high-caloric diet also didn’t have an impact.
Researchers also found evidence that the low sugar diet could have an influence on the human body.
“Low sugar diet is associated with decreased intestinal permeability,” said study author, David Hickey, professor of clinical pathology at Duke.
“In humans, we have lower intestinal permeabilities than animals and in people, our gut permeabilities have been shown to be very low.”
In humans and mice, the high sugar diet was associated with an increased number of immune cells in the intestine.
“That’s very significant because in humans, that’s a very common risk factor for cancer,” Hickey said.
“In mice, we see that it doesn’t happen that way, that the gut is able to get a lot of these protective cells, and we don’t have that same inflammatory response.”
The researchers think that the higher levels of intestinal permeablity seen in the mice on a low sugar, high fat and high carbohydrate diets may help explain why cancer develops so quickly in people.
They also found a link between how much sugar and fat people eat and the amount of inflammatory cells in their intestines.
“The gut-bacteria interaction was one of the strongest indicators of the association between these three foods and human disease risk,” Higgs said.
“It may have also been an important contributor to how the disease progresses in people.”
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